期刊
ORGANIC LETTERS
卷 20, 期 21, 页码 6845-6849出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02975
关键词
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资金
- National Institutes of Health (NIGMS) [R01GM110560]
- National Science Foundation and Environmental Protection Agency [CHE-1339674: NSMDS]
- NIH [S10RR028859]
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR028859] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM110560] Funding Source: NIH RePORTER
A convenient Cadiot-Chodkiewicz protocol that facilitates the use of low molecular weight alkyne coupling partners is described. The method entails an in situ elimination from a dibromoolefin precursor and immediate subjection to copper-catalyzed conditions, circumventing the hazards of volatile brominated alkynes. The scope of this method is described, and the internal 1,3-diyne products are preliminarily evaluated in ruthenium-catalyzed azide-alkyne cycloadditions.
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