期刊
ORGANIC LETTERS
卷 20, 期 20, 页码 6596-6600出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02961
关键词
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资金
- ANBG (Agence Nationale des Bourses du Gabon) [828988C]
- French ANR grant [ANR-15-CE29-0001]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE29-0001] Funding Source: Agence Nationale de la Recherche (ANR)
Theionbrunonines A and B (1 and 2), the first examples of monoterpene bisindole alkaloids linked by a thioether bridge, were isolated from the stems of Mostuea brunonis, guided by a molecular networking-based dereplication strategy. Their structures were elucidated by a combination of spectroscopic data and ECD calculations. A plausible biosynthetic pathway for 1 and 2 was postulated. Theionbrunonines A and B (1 and 2) showed moderate antiplasmodial activities in the micromolar range against the strain FcB1 of Plasmodium falciparum and no cytotoxic activity against the MRC-5 cell line at 20 mu M.
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