期刊
ORGANIC LETTERS
卷 21, 期 1, 页码 228-232出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03670
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资金
- North Carolina State University
- National Taiwan Normal University
- Ministry of Science and Technology, Taiwan [MOST 107-2113-M-003-002]
A complementary study including design of mechanistic probes, biochemical assays, model analysis, and liquid chromatography coupled mass spectrometry was conducted to establish the reaction mechanism for a nonheme iron enzyme catalyzed (-)-podophyllotoxin formation. Our results indicate that the originally proposed hydroxylated intermediate is unlikely to be involved in this reaction. Instead, the formation of benzylic radical/carbocation intermediate can be utilized to trigger the C-C bond formation to construct the C-ring of (-)-podophyllotoxin.
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