期刊
OPTICS EXPRESS
卷 26, 期 22, 页码 28808-28817出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.26.028808
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资金
- Human Frontiers Science Program [RGP0015/2016]
- Israeli Ministry of Science and Technology [712845]
- Azrieli Foundation
Multi-core fiber-bundle endoscopes provide a minimally-invasive solution for deep tissue imaging and opto-genetic stimulation, at depths beyond the reach of conventional microscopes. Recently, wavefront-shaping has enabled lensless bundle-based micro-endoscopy by correcting the wavefront distortions induced by core-to-core inhomogeneities. However, current wavefront-shaping solutions require access to the fiber distal end for determining the bend-sensitive wavefront-correction. Here, we show that it is possible to determine the wavefront correction in-situ, without any distal access. Exploiting the nonlinearity of two-photon excited fluorescence, we adaptively determine the wavefront correction in-situ using only proximal detection of epi-detected fluorescence. We experimentally demonstrate diffraction-limited, three-dimensional, two-photon lensless microendoscopy with commercially-available ordered and disordered multi-core fiber bundles. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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