期刊
NEUROSCIENCE RESEARCH
卷 139, 期 -, 页码 3-8出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2018.11.007
关键词
Neurons; Axon pruning; Apoptosis; Axon degeneration; Nerve growth factor; NGF; Compartmentalized cultures; Microfluidic chambers; Sympathetic neurons; Caspase 3; Caspase 6; Caspase 9; Bax; Apaf-1; Synaptic pruning
资金
- National Institutes of Health [GM118331]
Neurons are capable of degenerating their axons for the physiological clearance and refinement of unnecessary connections via the programmed degenerative pathways of apoptosis and axon pruning. While both pathways mediate axon degeneration they are however distinct. Whereas in apoptosis the entire neuron, both axons and cell body, degenerates, in the context of axon pruning only the targeted axon segments are selectively degenerated. Interestingly, the molecular pathways mediating axon degeneration in these two contexts have significant mechanistic overlap but also retain distinct differences. In this review, we describe the peripheral neuronal cell culture models used to study the molecular pathways of apoptosis and pruning. We outline what is known about the molecular mechanisms of apoptosis and axon pruning and focus on highlighting the similarities and differences of these two pathways. (C) 2018 Published by Elsevier B.V.
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