期刊
ACS NANO
卷 10, 期 3, 页码 3723-3737出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b00261
关键词
liposomes; cellular uptake; cell viability; QSAR protein corona; cancer
类别
资金
- Tehran University of Medical Sciences [94-04-33-31032]
- MIUR [RBFR08TLPO]
To control liposomes fate and transport upon contact with biofluids, it is essential to consider several parameters affecting the synthetic and biological identity of liposomes, as well as liposome protein corona (PC) aspects. As a powerful tool in this data mining adventure, quantitative structure activity relationship (QSAR) approach is used to correlate physicochemical properties of liposomes and their PC fingerprints to multiple quantified biological responses. In the present study, the relationship between cellular interactions of a set of structurally diverse liposomal formulations and their physicochemical and PC properties has been investigated via linear and nonlinear QSAR models. Significant parameters affecting cellular uptake and cell viability of liposomes in two important cancer cell lines (PC3 and HeLa) have been identified. The developed QSARs have the capacity to be implemented in advanced targeted delivery of liposomal drugs.
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