期刊
ACS NANO
卷 10, 期 12, 页码 11027-11036出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b05858
关键词
carbon monoxide; Prussian blue; iron carbonyl; laser ablation; anthracemia
类别
资金
- Ministry of Science and Technology, Taiwan [MOST 105-2119-M-006-023-MY2, MOST 103-2320-B-182A-004-MY3]
Carbon monoxide (CO) causes the dysfunction of mitochondria to induce the apoptosis of cancer cells giving a promising choice as an emerging treatment. The currently reported CO-based complexes still suffer from many limitations. Synthesis of CO-release carriers in the manner of on-demand control is highly anticipated. In this study, we present a near infrared (NIR) light-responsive CO-delivery nanocarrier, a PEGylated iron carbonyl derivatized Prussian blue (PB) nano particle (NP). Taking the structural characteristic containing Fe3+-N equivalent to C-Fe2+ unit, the -CN- served as the active sites for the coordination of iron carbonyl, while the surface Fe sites chelated with the amine-functionalized polyethylene glycol (NH2-PEG(6000)-Nliz) to yield PEGylated PB NPs carrying CO. The control of light intensity and exposure period is important to release the amount of CO as well as to deliver the hyperthermia effect. The combination therapy including CO and photothermal treatments displayed a synergistic effect against cancer cells. Importantly, the release of CO is inert in the blood circulation without MR irradiation. The blood oxygen saturation measured by the pulse oximeter and the HCO3, tCO(2)x, and pH values analyzed by the blood assay revealed the steady status from the mice studies, showing no acute CO poisoning.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据