期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 98, 期 -, 页码 256-264出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.01.018
关键词
Auditory cortex; Amygdala; Emotional memory; Fear learning; Anxiety disorders; Valence and salience
资金
- European Research Council (ERC) under the European Union [281072]
- 'Compagnia di San Paolo, Progetto d'Ateneo'-University of Turin 2017 [CSTO167503]
- European Research Council (ERC) [281072] Funding Source: European Research Council (ERC)
How and where sensory stimuli, such as tones or lights, are linked to valence is an important unresolved question in the field of neuroscience. The auditory cortex is essential to analyse the identity and the behavioural importance of tones paired with emotional events. On the contrary, whether the auditory cortex may also encode information on the emotional-motivational valence of sounds is much more controversial. Here, we reviewed recent studies showing that the activity of cortical neurons reflects information about the content of emotional stimuli paired with tones. Critically, the blockade of these neuronal processes prevents animals from recognising sounds as aversive or pleasant. Based on these findings, we proposed a conceptual model in which the auditory cortex may incorporate ascending information from subcortical nuclei about the valence of sounds in sound representations and may consequently drive the activity of subcortical structures towards emotionally laden tones. This hypothesis may also have important implications in the characterisation of neural circuits engaged by maladaptive affective disorders, such as phobias.
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