期刊
NEURON
卷 101, 期 2, 页码 207-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.12.006
关键词
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资金
- JPB Foundation
- Adelson Medical Research Foundation
- Vincent J. Coates Foundation
- NIH [R01 DA015043, R01 MH110504]
- Veterans Administration
- NOMIS Foundation
- Helen Hay Whitney Foundation
- National Multiple Sclerosis Society
- Life Science Research Foundation
- Stanford Medicine Dean's Fellowship
Microglia are increasingly recognized for their major contributions during brain development and neuro-degenerative disease. It is currently unknown whether these functions are carried out by subsets of microglia during different stages of development and adulthood or within specific brain regions. Here, we performed deep single-cell RNA sequencing (scRNA-seq) of microglia and related myeloid cells sorted from various regions of embryonic, early postnatal, and adult mouse brains. We found that the majority of adult microglia expressing homeostatic genes are remarkably similar in transcriptomes, regardless of brain region. By contrast, early postnatal microglia are more heterogeneous. We discovered a proliferative-region-associated microglia (PAM) subset, mainly found in developing white matter, that shares a characteristic gene signature with degenerative disease-associated microglia (DAM). Such PAM have amoeboid morphology, are metabolically active, and phagocytose newly formed oligodendrocytes. This scRNA-seq atlas will be a valuable resource for dissecting innate immune functions in health and disease.
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