期刊
NEURON
卷 100, 期 4, 页码 876-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.09.042
关键词
-
资金
- Howard Hughes Medical Institute
- Simons Collaboration on the Global Brain [325171, 542973, 325207]
- NIH grants from the NINDS [1U19NS104653, U01NS090449]
- Gatsby Charitable Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U19NS104653, U01NS090449] Funding Source: NIH RePORTER
Simultaneous recordings of large populations of neurons in behaving animals allow detailed observation of high-dimensional, complex brain activity. However, experimental approaches often focus on singular behavioral paradigms or brain areas. Here, we recorded whole-brain neuronal activity of larval zebrafish presented with a battery of visual stimuli while recording fictive motor output. We identified neurons tuned to each stimulus type and motor output and discovered groups of neurons in the anterior hindbrain that respond to different stimuli eliciting similar behavioral responses. These convergent sensorimotor representations were only weakly correlated to instantaneous motor activity, suggesting that they critically inform, but do not directly generate, behavioral choices. To catalog brain-wide activity beyond explicit sensorimotor processing, we developed an unsupervised clustering technique that organizes neurons into functional groups. These analyses enabled a broad overview of the functional organization of the brain and revealed numerous brain nuclei whose neurons exhibit concerted activity patterns.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据