期刊
NEURON
卷 101, 期 3, 页码 459-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.12.020
关键词
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资金
- European Research Council (ERC) under the European Union Horizon 2020 Research and Innovation Program [771411]
- Wellcome Trust [091543/Z/10/Z, 102160/Z/13/Z]
- Paul G. Allen Frontiers Group Allen Distinguished Investigator Award [12076]
- Medical Research Council studentship
- Gates Cambridge Trust Gates scholarship
- Biotechnology and Biological Sciences Research Council studentship
- Homerton College Cambridge junior research fellowship
- UK MS Society Cambridge Myelin Repair Centre grant [50]
- Fonds de Recherche du Quebec - Sante scholarship
- Cambridge Commonwealth, European and International Trust scholarship
- Lister Institute research prize
- Wellcome Trust [091543/Z/10/Z] Funding Source: Wellcome Trust
- European Research Council (ERC) [771411] Funding Source: European Research Council (ERC)
- MRC [G0701476, MC_PC_15042] Funding Source: UKRI
Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during CNS development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and, likewise, differentiation failure with age.
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