期刊
NEUROMOLECULAR MEDICINE
卷 21, 期 1, 页码 1-11出版社
HUMANA PRESS INC
DOI: 10.1007/s12017-018-08523-5
关键词
NRF2; NRF2 activator; Alzheimer's disease; Amyloid-beta; Oxidative stress; ROS; Neurodegenerative disease
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2012R1A5A2A28671860, 2017M3C7A1048268, 2018M3C7A1021851]
- Ministry of Education, Science and Technology, Republic of Korea
- National Research Foundation of Korea [2017M3C7A1048268] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/NRF2) is a master transcription factor that regulates oxidative stress-related genes containing the antioxidant response element (ARE) in their promoters. The damaged function and altered localization of NRF2 are found in most neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis. These neurodegenerative diseases developed from various risk factors such as accumulated oxidative stress and genetic and environmental elements. NRF2 activation protects our bodies from detrimental stress by upregulating antioxidative defense pathway, inhibiting inflammation, and maintaining protein homeostasis. NRF2 has emerged as a new therapeutic target in AD. Indeed, recent studies revealed that NRF2 activators have therapeutic effects in AD animal models and in cultured human cells that express AD pathology. This review will focus on the NRF2 pathway and the role of NRF2 in AD and suggest some NRF2 inducers as therapeutic agents for AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据