期刊
NEUROLOGY
卷 92, 期 3, 页码 E183-E193出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000006777
关键词
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资金
- French Ministry of Health (PHRC National 2009)
- FAPESP Foundation
ObjectiveTo analyze the factors that determine the occurrence or severity of postictal hypoxemia in the immediate aftermath of a generalized convulsive seizure (GCS).MethodsWe reviewed the video-EEG recordings of 1,006 patients with drug-resistant focal epilepsy included in the REPO2MSE study to identify those with 1 GCS and pulse oximetry (SpO(2)) measurement. Factors determining recovery of SpO(2) 90% were investigated using Cox proportional hazards models. Association between SpO(2) nadir and person- or seizure-specific variables was analyzed after correction for individual effects and the varying number of seizures.ResultsA total of 107 GCS in 73 patients were analyzed. A transient hypoxemia was observed in 92 GCS (86%). Rate of GCS with SpO(2) <70% dropped from 40% to 21% when oxygen was administered early (p = 0.046). Early recovery of SpO(2) 90% was associated with early administration of oxygen (p = 0.004), absence of postictal generalized EEG suppression (PGES) (p = 0.014), and extratemporal lobe epilepsy (p = 0.001). Lack of early administration of O-2 (p = 0.003), occurrence of PGES (p = 0.018), and occurrence of ictal hypoxemia during the focal phase (p = 0.022) were associated with lower SpO(2) nadir.ConclusionPostictal hypoxemia was observed in the immediate aftermath of nearly all GCS but administration of oxygen had a strong preventive effect. Severity of postictal hypoxemia was greater in temporal lobe epilepsy and when hypoxemia was already observed before the onset of secondary GCS.
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