期刊
ACS NANO
卷 10, 期 3, 页码 3149-3157出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b03060
关键词
tin tungstate; nanoparticle; photodynamic therapy; tumor; antimetastatic
类别
资金
- Virtual Helmholtz Center Solar-SynGas
- Chemical Industry Fund
- German National Academic Foundation
- Land-esgraduiertenforderung of Baden-Wurttemberg
- Biointerfaces Programme of Helmholtz-Association
- Karlsruhe Nano Micro Facility (KNMF)
The nanoparticulate inorganic photosensitizer beta-SnWO4 is suggested for photo dynamic therapy (PDT) of near-surface tumors via reiterated 5 min blue-light LED illumination. beta-SnWO4 nanoparticles are obtained via water-based synthesis and comprise excellent colloidal stability under physiological conditions and high biocompatibility at low material complexity. Antitumor and antimetastatic effects were investigated with a spontaneously metastasizing (4T1 cells) orthotopic breast cancer BALB/c mouse model. Besides protamine-functionalized beta-SnWO4 (23 mg/kg of body weight, in PBS buffer), chemotherapeutic doxorubicin was used as positive control (2.5 mg/kg of body weight, in PBS buffer) and physiological saline (DPBS) as a negative control. After 21 days, treatment with beta-SnWO4 resulted in a dearly inhibited growth of the primary tumor (all tumor volumes below 3 cm(3)) as compared to the doxorubicin and DPBS control groups (volumes up to 6 cm3). Histological evaluations of lymph nodes and lungs as well as the volume of ipsilateral lymph nodes show a remarkable antimetastatic effect being similar to chemotherapeutic doxorubicin but-according to blood counts-at significantly reduced side effects. On the basis of low material complexity, high cytotoxicity under blue-light LED illumination at low dark and long-term toxicity, beta-SnWO4 can be an interesting addition to PDT and the treatment of near-surface tumors, including skin cancer, esophageal/gastric/colon tumors as well as certain types of breast cancer.
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