期刊
NEUROCHEMISTRY INTERNATIONAL
卷 130, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2018.10.013
关键词
Ischemic brain injury; Immune system; Inflammation; Neural repair; Neuronal circuit remodeling; Neurogenesis
资金
- AMED [JP18gm5910023, JP18ek0210100]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [17K19571, 17H05096, 17H05514, 18K14831]
- Naito Foundation
- SENSHIN Medical Research Foundation
- MSD Life Science Foundation
- Ichiro Kanehara Foundation
- Kishimoto Foundation Research Grant
- Tokyo Biochemical Research Foundation
- Takeda Science Foundation
- Mitsubishi Foundation
- Grants-in-Aid for Scientific Research [17H05096, 18K14831, 17K19571, 17H05514] Funding Source: KAKEN
Stroke causes neuronal cell death and destruction of neuronal circuits in the brain and spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the extracellular release of endogenous molecules, but cerebral inflammation after stroke is gradually resolved within several days. In this pro-resolving process, inflammatory cells adopt a pro-resolving or repairing phenotype in the injured brain, activating endogenous repairing programs. Although the mechanisms involved in the transition from inflammation to neural repair after stroke remain largely unknown to date, some of the mechanisms for inflammation and neural repair have been clarified in detail. This review focuses on the molecular or cellular mechanisms involved in sterile inflammation and neural repair after stroke. This accumulation of evidence may be helpful for speculating about the endogenous repairing mechanisms in the brain and identifying therapeutic targets for improving the functional prognoses of stroke patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据