期刊
ACS NANO
卷 10, 期 8, 页码 7721-7730出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b03074
关键词
PEG-Ce 6 nanomicelles; PET imaging; fluorescence imaging; EPR effect; photodynamic therapy
类别
资金
- National Natural Science Foundation of China [51302180, 51572180]
- Postdoctoral Science Foundation of China [2013M531400, 2014T70542]
- Collaborative Innovation Center of Suzhou Nano Science and Technology (Nano-CIC)
- University of Wisconsin-Madison
- National Institutes of Health [NIBIB/NCI 1R01CA169365, P30CA014520, T32CA009206]
- American Cancer Society [125246-RSG-13-099-01-CCE]
- Office of the Director, National Institutes of Health [S10OD012245]
Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise in nanomedicine. Herein, we develop an organic photo dynamic therapy (PDT) system based on polyethylene glycol (PEG)-coated nanomicelles conjugated with similar to 20% chlorin e6 (PEG-Ce 6 nanomicelles), which functions as an optical imaging agent, as well as a PDT agent. The formed PEG-Ce 6 nanomicelles with the size of similar to 20 nm were highly stable in various physiological solutions for a long time. Moreover, Ce 6 can also be a Cu-64 chelating agent for in vivo positron emission tomography (PET). By simply mixing, more than 90% of Cu-64 was chelator-free labeled on PEG-Ce 6 nanomicelles, and they also showed high stability in serum conditions. Both fluorescence imaging and PET imaging revealed that PEG-Ce 6 nanomicelles displayed high tumor uptake (13.7 +/- 2.2%ID/g) after intravenous injection into tumor-bearing mice at the 48 h time point. In addition, PEG-Ce 6 nanomicelles exhibited excellent PDT properties upon laser irradiation, confirming the theranostic properties of PEG-Ce 6 nanomicelles for imaging and treatment of cancer. In addition, PDT was not shown to render any appreciable toxicity. This work presents a theranostic platform based on polymer nanomicelles with great potential in multimodality imaging guided photodynamic cancer therapy.
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