期刊
ACS NANO
卷 10, 期 3, 页码 2991-2994出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b00870
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资金
- Intramural NIH HHS [Z99 EB999999, ZIA EB000073-07] Funding Source: Medline
Both passive targeting and actively enhanced cellular internalization play significant roles in tumor-targeted therapy. Programmed specific targeting, as a novel targeting strategy that exploits stimuli-responsive structures, expects that nanocarriers show high stability during blood circulation for efficient passive targeting, then respond to tumor internal or external stimuli and transform into more cell-interactive forms upon arrival at the tumor tissue for enhanced cellular internalization. In this Perspective, we introduce recent advances in the design and development of stimuli-responsive programmed specific targeting nanomedicines, which are based on switchable surface charge, activatable targeting molecules, and variable coatings, to combine the advantages of passive targeting and actively enhanced cellular internalization.
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