期刊
ACS NANO
卷 10, 期 2, 页码 2375-2385出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b07172
关键词
Au nanorods; CXCR4; induced pluripotent stem cells; photothermal therapy
类别
资金
- National Key Basic Research Program [2015CB931802]
- National Natural Scientific Fund [81225010, 81327002, 31100717]
- 863 Project of China [2014AA020700]
- Shanghai Science and Technology Fund [13NM1401500, 15DZ2252000]
How to improve effective accumulation and intratumoral distribution of plasmonic gold nanoparticles has become a great challenge for photothermal therapy of tumors. Herein, we reported a nanoplatform with photo thermal therapeutic effects by fabricating Au nanorods@SiO2@CXCR4 nanoparticles and loading the prepared nanoparticles into the human induced pluripotent stem cells (AuNRs-iPS). In virtue of the prominent optical properties of Au nanorods@SiO2@CXCR4 and remarkable tumor target migration ability of iPS cells, the Au nanorods delivery mediated by iPS cells via the nanoplatform AuNRs-iPS was found to have a prolonged retention time and spatially even distribution in MGC803 tumor-bearing nude mice observed by photoacoustic tomography and two-photon luminescence. On the basis of these improvements, the nanoplatform displayed a robust migration capacity to target the tumor site and to improve photothermal therapeutic efficacy on inhibiting the growth of tumors in xenograft mice under a low laser power density. The combination of gold nanorods with human iPS cells as a theranostic platform paves an alternative road for cancer theranostics and holds great promise for clinical translation in the near future.
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