期刊
ACS NANO
卷 10, 期 5, 页码 5015-5026出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b07200
关键词
surface-enhanced Raman scattering; nanoparticles; hepatocellular carcinoma; sarcoma; intraoperative imaging; image-guided tumor resection
类别
资金
- NIH [R01 EB017748, K08 CA16396, 5P01 CA013106, 5U01 CA168409]
- Damon Runyon Cancer Research Foundation [DRR-29-14]
- Pershing Square Sohn Prize
- Dana Foundation Brain and Immuno-Imaging Grant
- Dana Neuroscience Scholar Award
- Geoffrey Beene Cancer Research Center at MSKCC Grant Award
- Shared Resources Award
- Bayer HealthCare Pharmaceuticals/RSNA Research Scholar Grant
- Center for Molecular Imaging & Nanotechnology (CMINT) Grant
- Center for Experimental Therapeutics of Memorial Sloan Kettering Cancer Center
- Molecularly Targeted Intra-Operative Imaging Grants
- Mr. William H. and Mrs. Alice Goodwin and the Commonwealth Foundation for Cancer Research
- MSKCC Office of Technology TDF Grant
- Society of MSKCC Research Grant
- Deutsche Forschungsgemeinschaft (DFG) [NE 1922/2-1]
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
Complete surgical resection is the ideal first line treatment for most liver malignancies. This goal would be facilitated by an intraoperative imaging method that enables more precise-visualization of tumor margins and detection of otherwise in-visible microscopic lesions. To this end, we synthesized silica-encapsulated surface-enhanced Raman scattering (SERS) nanoparticles (NPs) that act as a molecular imaging agent for liver malignancies. We hypothesized that, after intravenous administration, SERS NPs would avidly home to healthy liver tissue but not to intrahepatic malignancies. We tested these SERS NPs in genetically engineered mouse models of hepatocellular carcinoma and histiocytic sarcoma. After intravenous injection, liver tumors in both models were readily identifiable with Raman imaging. In addition, Raman imaging using SERS NPs enabled detection of microscopic lesions in liver and spleen. We compared the performance of SERS NPs to fluorescence imaging using indocyanine green (ICG). We found that SERS NPs delineate tumors more accurately and are less susceptible to photobleaching. Given the known advantages of SERS imaging, namely, high sensitivity and specific spectroscopic detection, these findings hold promise for improved resection of liver cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据