期刊
ACS NANO
卷 10, 期 9, 页码 8732-8737出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b04207
关键词
antimicrobial activity; size; charge orientation; zwitterionic gold nanoparticles
类别
资金
- NIGMS NIH HHS [R01 GM077173] Funding Source: Medline
Zwitterionic nanoparticles are generally considered nontoxic and noninteracting. Here, we report effective and selective antimicrobial activity of zwitterionic gold nanoparticles (AuNP) through modulation NP size and surface charge orientation. Using a set of 2, 4, and 6 nm core AuNPs, increasing particle size increased antimicrobial efficiency through bacterial membrane disruption. Further improvement was observed through control of the ligand structure, generating antimicrobial particles with low hemolytic activity and demonstrating the importance of size and surface structure in dictating the bioactivity properties of nanomaterials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据