期刊
ACS NANO
卷 10, 期 4, 页码 4459-4471出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b00130
关键词
nanotechnology; graphene; patch-clamp; synaptic terminals; exocytosis; FMI-43; microvesicles
类别
资金
- Wellcome Trust
- BBSRC
- University of Manchester Strategic Fund
- EU FP7-ICT-FET-F GRAPHENE Flagship project from the NEUROSCAFFOLDS-FP7-NMP [604391, 604263]
- PRIN-MIUR [2012MYESZW]
- EPSRC [EP/K005014/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K005014/1] Funding Source: researchfish
Graphene offers promising advantages for biomedical applications. However, adoption of graphene technology in biomedicine also poses important challenges in terms of understanding cell responses, cellular uptake, or the intracellular fate of soluble graphene derivatives. In the biological microenvironment, graphene nanosheets might interact with exposed cellular and subcellular structures, resulting in unexpected regulation of sophisticated biological signaling. More broadly, biomedical devices based on the design of these 2D planar nanostructures for interventions in the central nervous system require an accurate understanding of their interactions with the neuronal milieu. Here, we describe the ability of graphene oxide nanosheets to down-regulate neuronal signaling without affecting cell viability.
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