期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 20, 期 5, 页码 267-284出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0092-0
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类别
资金
- European Research Council (ERC) [648235]
- Excellence Initiative and Strategy of the German federal and state governments [EXC 294 BIOSS, EXC 2189 CIBSS]
- Excellence Initiative and Strategy of the German federal and state governments (GSC-4 Spemann Graduate School)
- Deutsche Forschungsgemeinschaft [PF 202/8-1, PF 202/9-1, WA 1598/5-1]
- [Sonderforschungsbereiche 746]
- [1140]
Mitochondria are essential for the viability of eukaryotic cells as they perform crucial functions in bioenergetics, metabolism and signalling and have been associated with numerous diseases. Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization. Protein machineries with diverse functions such as protein translocation, respiration, metabolite transport, protein quality control and the control of membrane architecture interact with each other in dynamic networks. In this Review, we discuss the emerging role of the mitochondrial protein import machinery as a key organizer of these mitochondrial protein networks. The preprotein translocases that reside on the mitochondrial membranes not only function during organelle biogenesis to deliver newly synthesized proteins to their final mitochondrial destination but also cooperate with numerous other mitochondrial protein complexes that perform a wide range of functions. Moreover, these protein networks form membrane contact sites, for example, with the endoplasmic reticulum, that are key for integration of mitochondria with cellular function, and defects in protein import can lead to diseases.
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