期刊
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
卷 16, 期 4, 页码 221-234出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41575-018-0097-3
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资金
- FIS [PI17/00012]
- Spanish Ministry of Science, Innovation and Universities
- Biomedical Research Network Center in Hepatic and Digestive Diseases (CIBEREHD)
- European Union Funds FEDER una manera de hacer Europa
- Stiftung fur Leberkrankheiten
- Instituto de Salud Carlos III [CD15/00050]
The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells (LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in liver homeostasis, including in preserving hepatocyte function, regulating the vascular tone and controlling inflammation. Liver microcirculatory dysfunction is one of the key mechanisms that promotes the progression of chronic liver disease (also termed cirrhosis) and the development of its major clinical complication, portal hypertension. In the present Review, we describe the current knowledge of liver microcirculatory dysfunction in cirrhotic portal hypertension and appraise the preclinical models used to study the liver circulation. We also provide a comprehensive summary of the promising therapeutic options to target the liver microvasculature in cirrhosis.
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