期刊
NATURE METHODS
卷 15, 期 12, 页码 1033-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41592-018-0184-y
关键词
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资金
- China MOST [2012YQ03026005, 2013ZX0950910, 2015BAI08B02, 2015CB755602]
- NNSFC [91432114, 91632302]
- Science Fund for Creative Research Group of China [61721092]
- Beijing Municipal Government
We developed a dual-adeno-associated-virus expression system that enables strong and sparse labeling of individual neurons with cell-type and projection specificity. We demonstrated its utility for whole-brain reconstruction of midbrain dopamine neurons and striatum-projecting cortical neurons. We further extended the labeling method for rapid reconstruction in cleared thick brain sections and simultaneous dual-color labeling. This labeling system may facilitate the process of generating mesoscale single-neuron projectomes of mammalian brains.
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