期刊
NATURE MEDICINE
卷 24, 期 12, 页码 1804-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41591-018-0238-9
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资金
- MD Anderson Cancer Center's Melanoma Moon Shot Program [710499-80-111538-19]
- American Association for Cancer Research Stand Up to Cancer [SU2C-AACR-IRG-19-17]
- National Institutes of Health [R01 CA219896-01A1, R01 HL124112]
- Cancer Prevention and Research Institute of Texas [RR160089]
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.
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