期刊
NATURE MEDICINE
卷 24, 期 12, 页码 1830-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41591-018-0196-2
关键词
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资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2018R1C1B5043901]
- NRF - Korean government (MEST) [2011-0028612]
- National Natural Science Foundation of China [11402134]
- National Science Foundation [1400169, 1534120, 1635443]
- DARPA
- Center for Bio-Integrated Electronics at Northwestern University
- Ministry of Science & ICT (MSIT), Republic of Korea [KIHST01] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1400169] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1635443] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1534120] Funding Source: National Science Foundation
Peripheral nerve injuries represent a significant problem in public health, constituting 2-5% of all trauma cases(1). For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function(2). Numerous studies report the potential of pharmacological approaches (for example, growth factors, immunosuppressants) to accelerate and enhance nerve regeneration in rodent models(3-10). Unfortunately, few have had a positive impact in clinical practice. Direct intraoperative electrical stimulation of injured nerve tissue proximal to the site of repair has been demonstrated to enhance and accelerate functional recovery(11,12), suggesting a novel nonpharmacological, bioelectric form of therapy that could complement existing surgical approaches. A significant limitation of this technique is that existing protocols are constrained to intraoperative use and limited therapeutic benefits(13). Herein we introduce (i) a platform for wireless, programmable electrical peripheral nerve stimulation, built with a collection of circuit elements and substrates that are entirely bioresorbable and biocompatible, and (ii) the first reported demonstration of enhanced neuroregeneration and functional recovery in rodent models as a result of multiple episodes of electrical stimulation of injured nervous tissue.
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