期刊
NATURE IMMUNOLOGY
卷 19, 期 12, 页码 1391-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-018-0236-6
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资金
- Uehara Memorial Foundation Research Fellowship
- MSD Life Science Foundation Research Fellowship
- Tomy Digital Biology
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), JSPS KAKENHI [21229010]
- Core Research for Evolutional Science and Technology (CREST) program from the Japan Science and Technology Agency
- National Institutes of Health [P01 AI045757, U19 AI046130, U19 AI070352, P01 AI039671]
- Nancy Taylor Foundation for Chronic Diseases
- BioLegend
Foxp3(+) regulatory T cells (T-reg cells) are the central component of peripheral immune tolerance. Whereas a dysregulated T-reg cytokine signature has been observed in autoimmune diseases, the regulatory mechanisms underlying pro- and anti-inflammatory cytokine production are elusive. Here, we identify an imbalance between the cytokines IFN-gamma and IL-10 as a shared T-reg signature present in patients with multiple sclerosis and under high-salt conditions. RNA-sequencing analysis on human T-reg subpopulations revealed beta-catenin as a key regulator of IFN-gamma and IL-10 expression. The activated beta-catenin signature was enriched in human IFN-gamma(+) T-reg cells, as confirmed in vivo with T-reg-specific beta-catenin-stabilized mice exhibiting lethal autoimmunity with a dysfunctional Treg phenotype. Moreover, we identified prostaglandin E receptor 2 (PTGER2) as a regulator of IFN-gamma and IL-10 production under a high-salt environment, with skewed activation of the beta-catenin-SGK1-Foxo axis. Our findings reveal a novel PTGER2-beta-catenin loop in T-reg cells linking environmental high-salt conditions to autoimmunity.
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