期刊
NATURE GENETICS
卷 51, 期 1, 页码 26-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41588-018-0272-z
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资金
- University of North Carolina at Chapel Hill University Cancer Research Fund (Tier 1 Development Award)
- North Carolina Translational and Clinical Sciences Institute [2KR851610]
- National Institute of Child Health and Development [5R01HD036655]
- National Institute of General Medical Sciences [5F32GM108367, R01GM121806]
SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner.
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