期刊
NATURE GENETICS
卷 51, 期 1, 页码 163-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-018-0262-1
关键词
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资金
- Wellcome [206194, WT104104/Z/14/Z, 104958]
- Medical Research Council [MR/L001020/1]
- Biotechnology and Biological Sciences Research Council [BB/K020048/1]
- US National Institutes of Health (NIH)-National Human Genome Research Institute [U54HG003079]
- National Institute of Allergy and Infectious Diseases [AI081803]
- National Institute of General Medical Sciences [GM097435]
- EU SICA award [242131]
- EU project EPIAF
- BBSRC/Edinburgh University
- Edinburgh University/James Hutton Institute PhD scholarship
- MRC [MR/K01207X/1]
- National Institutes of Health/NIAID [R21 AI126466]
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2014-06664]
- Wellcome Investigator Award [106122]
- Wellcome core funding [104111]
- Scottish Government RESAS
- Institute of Parasitology, BC CAS [RVO: 60077344]
- Member States of the European Molecular Biology Laboratory (EMBL)
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI081803, K22AI125473] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM097435] Funding Source: NIH RePORTER
- BBSRC [BB/M003949/1, BB/P024610/1, BB/P024602/1, BB/R015325/1, BB/K020048/1] Funding Source: UKRI
- MRC [MR/L001020/1, MC_PC_18048, MR/S000453/1] Funding Source: UKRI
Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.
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