期刊
ACS NANO
卷 10, 期 6, 页码 5800-5808出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b08081
关键词
optical trapping; optical detection; nanoparticles; subwavelength cells; photonic nanojets
类别
资金
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13042]
- National Natural Science Foundation of China [61205165]
In advanced nanoscience, there is a strong desire to trap and detect nanoscale objects with high-throughput, single-nanoparticle resolution and high selectivity. Although emerging optical methods have enabled the selective trapping and detection of multiple micrometer-sized objects, it remains a great challenge to extend this functionality to the nanoscale. Here, we report an approach to trap and detect nanoparticles and subwavelength cells at low optical power using a parallel photonic nanojet array produced by assembling microlenses on an optical fiber probe. Benefiting from the subwavelength confinement of the photonic nanojets, tens to hundreds of nanotraps were formed in three dimensions. Backscattering signals were detected in real time with single-nanoparticle resolution and enhancement factors of 10(3)-10(4). Selective trapping of nanoparticles and cells from a particle mixture or human blood solution was demonstrated using the nanojet array. The developed nanojet array is potentially a powerful tool for nanoparticle assembly, biosensing, single-cell analysis, and optical sorting.
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