期刊
NATURE CELL BIOLOGY
卷 21, 期 1, 页码 94-101出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0249-2
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资金
- Deutsche Forschungsgemeinschaft [SCHM 1633/9-1, SCHM 1633/11-1]
- Helmholtz Alliance 'Preclinical Comprehensive Cancer Center' grant from the Helmholtz Association [HA-305]
- Deutsche Krebshilfe [110678]
- Berlin School of Integrative Oncology (BSIO) graduate program within the German Excellence Initiative
- German Cancer Consortium
Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy, and characterize these properties, such as reprogramming into stemness, tissue remodelling and immune crosstalk, as far more dynamic than suggested by the common view of senescence as an irreversible, static condition.
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