期刊
NATURE CELL BIOLOGY
卷 20, 期 11, 页码 1240-1249出版社
NATURE PORTFOLIO
DOI: 10.1038/s41556-018-0214-0
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资金
- NIH/NCI [U54CA193461-01, R01 CA114536]
- Era of Hope Award from the United States Department of Defence Breast Cancer Research Program [W841XWH-15-1-0201]
- Breast Cancer Research Foundation [IIDRP-17-001]
- W.M. Keck Foundation
- National Breast Cancer Coalition's Artemis Project
Despite increased focus on the clinical relevance of dormant metastatic disease, our understanding of dormant niches, mechanisms underlying emergence from dormancy, and the immune system's role in this phenomenon, remains in its infancy. Here, we discuss key work that has shaped our current understanding of these topics. Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease.
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