期刊
NATURE CELL BIOLOGY
卷 21, 期 1, 页码 63-71出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0205-1
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资金
- National Research Foundation of Korea - Ministry of Education in Korea [2015R1D1A1A01059401, 2018R1D1A1B07048869]
- National Institutes of Health [GM51586, CA196878, CA217642]
- NATIONAL CANCER INSTITUTE [R35CA196878] Funding Source: NIH RePORTER
The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally known as mammalian target of rapamycin) is a central cell growth regulator connecting cellular metabolism and growth with a wide range of environmental inputs as part of mTOR complex 1 (mTORC1) and mTORC2. In this Review, we introduce the landmark discoveries in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations of key components of the mTORC signalling network with an emphasis on amino acid sensing, and discuss the perspectives of mTORC inhibitors in therapeutic applications.
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