期刊
NATURE CELL BIOLOGY
卷 21, 期 2, 页码 122-132出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0223-z
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资金
- Academy of Finland
- ERC Consolidator Grant [615258]
- Sigrid Juselius Foundation
- Cancer Society of Finland
- EMBO Long-Term Fellowship [ALTF 405-2018]
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.
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