期刊
ACS NANO
卷 10, 期 6, 页码 5720-5729出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b07276
关键词
hydrophobic drugs; nanoengineering; interfacial assembly; Ostwald ripening suppression; drug delivery
类别
资金
- National Natural Science Foundation of China [21522307, 21473208, 91434103, 81402871]
- Talent Fund of the Recruitment Program of Global Youth Experts
- Beijing Natural Science Foundation [7154220]
- CAS [2016VTA042]
- Chinese Academy of Sciences (CAS)
The majority of anticancer drugs are poorly water-soluble and thus suffer from rather low bioavailability. Although a variety of delivery carriers have been developed for bioavailability improvement, they are severely limited by low drug loading and undesired side effects. The optimum delivery vehicle would be a biocompatible and biodegradable drug nanoparticle of uniform size with a thin but stable shell, making it soluble, preventing aggregation and enabling targeting. Here, we present a general strategy for the rational design of hydrophobic drug nanoparticles with high drug loading by means of interfacial cohesion and supramolecular assembly of bioadhesive species. We demonstrate that the pathway is capable of effectively suppressing and retarding Ostwald ripening, providing drug nanoparticles with small and uniform size and long-term colloidal stability. The final complex drug nanoparticles provide higher tumor accumulation, negligible toxicity, and enhanced antitumor activity, superior to commercial formulations. Our findings demonstrate that local, on-demand coating of hydrophobic nanoparticles is achievable through cooperation and compromise of interfacial adhesion and assembly.
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