期刊
NATURE
卷 565, 期 7738, 页码 246-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41586-018-0824-5
关键词
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资金
- JSPS KAKENHI [JP17H06175, JP18H05376]
- AMED-CREST [JP18gm0510019, JP18gm1110009]
- AMED-PRIME [JP18gm5910023]
- AMED [JP18ek0210100]
- Takeda Science Foundation
- Uehara Memorial Foundation
- Kanae Foundation
- SENSHIN Medical Research Foundation
- Keio Gijuku Academic Developmental Funds
- JSPS post-doctoral fellowship
In addition to maintaining immune tolerance, FOXP3(+) regulatory T (T-reg) cells perform specialized functions in tissue homeostasis and remodelling(1,2). However, the characteristics and functions of brain Treg cells are not well understood because there is a low number of Treg cells in the brain under normal conditions. Here we show that there is massive accumulation of T-reg cells in the mouse brain after ischaemic stroke, and this potentiates neurological recovery during the chronic phase of ischaemic brain injury. Although brain T-reg cells are similar to Treg cells in other tissues such as visceral adipose tissue and muscle(3-5), they are apparently distinct and express unique genes related to the nervous system including Htr7, which encodes the serotonin receptor 5-HT7. The amplification of brain T-reg cells is dependent on interleukin (IL)-2, IL-33, serotonin and T cell receptor recognition, and infiltration into the brain is driven by the chemokines CCL1 and CCL20. Brain T-reg cells suppress neurotoxic astrogliosis by producing amphiregulin, a low-affinity epidermal growth factor receptor (EGFR) ligand. Stroke is a leading cause of neurological disability, and there are currently few effective recovery methods other than rehabilitation during the chronic phase. Our findings suggest that T-reg cells and their products may provide therapeutic opportunities for neuronal protection against stroke and neuroinflammatory diseases.
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