期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 11, 页码 1499-1504出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1493736
关键词
Tunicamycin; nucleotide antibiotics; Streptomyces xinghaiensis; antimicrobial activity
资金
- National Natural Science Foundation of China [81425022, U1501223, U1706206]
- Natural Science Foundation of Guangdong Province [2016A030312014]
Tunicamycin E (1), featuring a methyl substitution at C-10 ', was isolated from marine-derived Streptomyces xinghaiensis SCSIO S15077 originated from the South China Sea sediment together with six known compounds, tunicamycin B (2), tunicamycin X (3), tunicamycin A (4), streptovirudin D-2 (5), tunicamycin C (6), and tunicamycin C-3 (7). The structure of compound 1 was elucidated by detailed spectroscopic data analyses. All the compounds exhibited strong to moderate antibacterial activity against Gram-positive bacteria Bacillus thuringiensis BT01 and B. thuringiensis W102 with MIC values ranging from 0.008 to 2 mu g/mL. Moreover, compounds 1-7 exhibited moderate antifungal activity against Candida albicans ATCC 96901 and C. albicans CMCC (F) 98001 with MIC values ranging from 2 to 32 mu g/mL. This is the first report that tunicamycins exhibit antimicrobial activities against B. thuringiensis, C. albicans CMCC (F) 98001 and a fluconazole resistant strain C. albicans ATCC 96901.
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