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Penicindopene A, a new indole diterpene from the deep-sea fungus Penicillium sp. YPCMAC1

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NATURAL PRODUCT RESEARCH
卷 33, 期 20, 页码 2988-2994

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TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1514402

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Indole diterpene; deep-sea fungus; Penicillium sp; YPCMAC1; cytotoxicity

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A new indole diterpene, named penicindopene A (1), together with seven known compounds (2 - 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for the assignments of its absolute configuration. Penicindopene A represented the first example of indole diterpenes possessing a 3-hydroxyl-2-indolone moiety, and it exhibited moderate cytotoxicities against A549 and HeLa cell lines with IC50 values of 15.2 and 20.5 mu M, respectively.

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