期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 6, 页码 880-883出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1504048
关键词
Uvaria chamae; composition; essential oil; antiglycation; antioxidant; cytotoxicity
资金
- Tertiary Education Trust Fund (TETFund)-Institutional Based Research Projects Intervention
Uvaria chamae (Annonaceae), is an essential oil bearing plant; the root is acclaimed as an effective remedy for folkloric diabetic therapy. The root extracts were evaluated for composition, antiglycation, antioxidant, and cytotoxicity. Flavonoids, cardiac glycosides, and tannins were relatively high in the alcohol extract; benzyl benzoate (23.3%), dimethoxy-p-cymene (14.2%), tau-cadinol (12.1%), and methyl thymol (8.7%) predominated the constituents identified by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The ethanol extract demonstrated significant antiglycation activity (IC50, 1.12 mg/mL), and cytotoxicity to brine shrimp (LC50, 25.01 mu g/mL). The extract (IC50, 8.0 mu g/mL; absorbance 0.531, 100 mu g/mL) also exhibited better antioxidant effects compared with the essential oil (IC50, 50.0 mu g/mL; absorbance 0.292, 100 mu g/mL) using 2,2-diphenyl-1-picrylhydrazyl radical and ferric reducing power assays respectively. U. chamae root possess antiglycation effect, and may also reduce oxidative stress in patients with diabetes; its antiglycation effect, oil composition, and cytotoxicity are reported for the first time. [GRAPHICS] .
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