期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 15, 页码 2262-2265出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1493583
关键词
Meroterpenoid; terretonin; structure elucidation; fungal metabolite; marine-derived Aspergillus terreus
资金
- National Natural Science Foundation of China [81500659]
- Science and Technology Development Plan of Henan Province [172102410020, 172102310450]
- Doctor Research Start-up Fund of Zhoukou Normal University [ZKNUC2016028]
- Scientific Research and Innovation Fund of Zhoukou Normal University [ZKNUA201804]
A new meroterpenoid, named terretonin D1 (1), and three known ones, terretonin (2), terretonin A (3), and terretonin D (4), were isolated from marine-derived fungus Aspergillus terreus ML-44. The structure of 1 was elucidated by extensive spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and the absolute configuration was determined by X-ray crystallographic analysis. The anti-inflammation activity of 1-4 was preliminarily tested, and all of them weakly inhibited the nitric oxide (NO) production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS), with inhibitory rates of 22-34% at 50 mu g/mL. [GRAPHICS] .
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