期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 20, 页码 2964-2969出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1512991
关键词
Buttercup family; Thalictrum genus; Thalictrum microgynum Lecoy; ex Oliv; benzophenanthridine alkaloid
A new benzophenanthridine alkaloid, 2,3,9-trimethoxy-7,8-methylenedioxy-5-methylbenzo[c]-6(5H) phenanthridone (2) and a benzophenanthridine alkaloid first found from natural sources, 2,3-dimethoxy-7,8- methylenedioxy-5-methylbenzo[c]-6(5H)- phenanthridone (1) together with two known benzophenanthridine alkaloids, Dihydrosanguinarine (3) and Dihydrochelilutine (4) were isolated from the roots of Thalictrum microgynum Lecoy.ex Oliv. The structures of 1 and 2 were elucidated using various spectroscopic techniques including HRESIMS and 1 D and 2 D NMR. Antibacterial activity of these compounds were tested. Compound 1, 3 and 4 showed antibacterial activity against Staphylococcus aureus with MIC values of 50, 100, 25 mu g/mL, respectively.
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