期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 18, 页码 2683-2688出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1550760
关键词
Pitanga; Jaboticaba; phenolic; EMMA; acetylcholinesterase; alpha-glucosidase
资金
- CAPES
- CNPq
- FURB
- UFSC
- INCT-Catalise
Alzheimer's disease and diabetes mellitus are contemporary diseases of great concern. Phenolic compounds are linked to several health benefits and could lead to novel strategies to combat these ailments. The objective of this study was to evaluate by electrophoretically-mediated microanalysis the potential inhibitory activity of the fruit juices fromPlinia cauliflora(jaboticaba) andEugenia uniflora(pitanga) toward acetylcholinesterase (AChE) and alpha-glucosidase, target enzymes in strategies for the treatment of these diseases. The phenolic profiles of the samples were also investigated. Jaboticaba and pitanga juices inhibited 85.90 +/- 1.73 and 52.67 +/- 1.24% of AChE activity at 5 mg mL(-1), and 57.91 +/- 2.60 and 69.47 +/- 2.89% of alpha-glucosidase activity at 1 mg mL(-1), respectively. Total phenolic content of the juices were 303.54 +/- 28.28 and 367.00 +/- 11.42 mgGA L-1, respectively. The observed inhibitory activity can be explained, at least in part, by the presence of the phenolic compounds. [GRAPHICS] .
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