期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 18, 页码 2694-2697出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1550765
关键词
Nauclea officinalis; indole alkaloid; anti-inflammatory effect; NO; iNOS
资金
- Shandong Province Natural Science Foundation [ZR2016HL54]
- Undergraduate Scientific and Technological Innovation Project of Yantai University
Naucleoffieine H, a natural indole alkaloid, was isolated and identified from Nauclea officinalis Pierrc ex Pitard which is a traditional Chinese medicine used for the treatment of various diseases, such as cold, fever, bronchitis, pneumonia, acute tonsillitis, etc. In the present study, the effect of naucleoffieine H on the anti-inflammatory activities was investigated in LPS-induced RAW 264.7 macrophages. The results showed that naucleoffieine H significantly inhibited the release of nitric oxide (the level of nitrite as a stable biomarker of NO production) and tumor necrosis factor-alpha (TNF-alpha). Interesting, naucleoffieine H down-regulated the overexpression of inflammatory protein induced nitric oxide synthase (iNOS), but no effect on the expression cyclooxygenase-2 (COX-2) protein. In addition, this bioactive alkaloid suppressed enzymatic activity of iNOS activated by LPS. The above results indicated that naucleoffieine H suppress NO and TNF-alpha overproduction via block the iNOS pathway in LPS-induced RAW 264.7 macrophages. [GRAPHICS]
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