期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 10, 页码 1409-1416出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1508150
关键词
Gracilaria salicornia {(C.Agardh) EYDawson}; Gracilariaceae; 16(13 -> 14)-abeo labdane; anti-inflammatory; antioxidant
资金
- Science and Engineering Research Board [SR/S1/OC96A/2012]
- Department of Science and Technology, New Delhi, India
Phytochemical investigation on the biologically active compounds of seaweed Gracilaria salicornia {(C. Agardh) E.Y. Dawson} (family Gracilariaceae) guided to the separation of a previously unreported abeo-labdane class of diterpenoid. The compound was characterized as methyl-16(13 -> 14)-abeo-7-labdene-(12-oxo) carboxylate by extensive spectroscopic experiments, and comparison with the related compounds. The studied compound registered significantly greater activities against pro-inflammatory 5-lipoxygenase (IC50 0.86 mg/mL) than that exhibited by non-steroidal anti-inflammatory agent ibuprofen (IC50 0.92 mg/mL, P < 0.05). Likewise, this compound exhibited comparable radical quenching (1, 1-diphenyl-2-picryl-hydrazil) activity (IC50 0.66 mg/mL) as standard antioxidant agent alpha-tocopherol (IC50 0.62 mg/mL).
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