期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 9, 页码 1219-1226出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1556266
关键词
Deep-sea-derived fungus; Cladosporium sp; SCSIO z015; citrinin derivative; toxicity; antioxidant
资金
- Natural Science Foundation of China [81673326]
- Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences [XDA100304002]
- Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development [GD2012-D01-002]
- CAS-TWAS President's Fellowship for International PhD Students
During the course of our search for novel bioactive compounds from marine fungi, four new citrinin derivatives, cladosporins A-D (1-4) were isolated from a culture broth of the deep-sea-derived fungus Cladosporium sp. SCSIO z015. Their complete structural assignments were elucidated by the extensive spectroscopic investigation. The absolute configurations of 1-3 were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compounds 1-4 showed weak toxicity towards brine shrine naupalii with LC50 values of 72.0, 81.7, 49.9 and 81.4 mu M, respectively. And 4 also showed significant antioxidant activity against & x251;,alpha-diphenyl-picrylhydrazyl (DPPH) radicals with an IC50 value of 16.4 mu M.
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