期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 18, 页码 2660-2663出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2018.1548454
关键词
Valtrate; breast cancer; apoptosis; migration
资金
- Zhejiang Provincial Department of Education Research Fund Project [Y201738463]
- National student innovation and entrepreneurship training program [201710344015]
- Zhejiang Chinese Medical University [2018ZZ09]
Valtrate is a principle compound isolated fromValeriana jatamansi Jones, a traditional Chinese folk medicine originally used to treat various nervous disorders. Here, we found that valtrate exhibited significant anti-cancer activityin vitro, especially in human breast cancer cells, while displayed relatively low cytotoxicity to normal human breast epithelial cells (MCF 10A). Valtrate induced cell cycle arrest at G2/M stage and apoptosis in MDA-MB-231 and MCF-7 cells, with reduced expression of p-Akt (Ser 473), cyclin B1 and caspase 8, and increased expression of p21, p-cdc2, cleaved-caspase 3, cleaved-caspase 7 and poly (ADP-ribose) polymerase (PARP). In addition, valtrate inhibited cell migration through down-regulation of MMP-9 and MMP-2 expression. These results demonstrate that valtrate possesses anti-breast cancer activities via cell cycle arrest, apoptosis, and inhibition of cell migration, thus supporting valtrate as a potential antitumor agent.
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