期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 15, 期 1, 页码 142-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.09.008
关键词
Synergistic antitumor; Drug delivery system; Wedelolactone; Indocyanine green; Graphene oxide
资金
- National Natural Science Foundation [21476190, 21776238]
- Hebei province key basic research Foundation [15961301D]
- Hebei Province higher education science and technology research Project [ZD2017084]
A multifunctional antitumor drug delivery system was synthesized based on graphene oxide (GO) for near-infrared (NIR) light controlling chemotherapeutic/photothermal (PTT) /photodynamic (PDT) trimodal synergistic therapy. The system named ICG-Wed-GO was formed by co-loading wedelolactone (Wed) and indocyanine green (ICG) on the surface of GO through pi-pi stacking interaction. Under NIR laser irradiation, ICG-Wed-GO could effectively absorb and transform optical energy to heat, generate reactive oxygen species (ROS) to ablating and damage tumor cells. The temperature of ICG-Wed-GO solution reached up to 79.4 degrees C in 10 min with NIR irradiation. In in vitro and in vivo study, ICG-Wed-GO showed excellent antitumor effect. After 14-day treatment of ICG-Wed-GO with NIR laser irradiation, the tumor disappeared completely on tumor-bearing mice. The low biotoxicity of ICG-Wed-GO was also proved. The system achieved the synergistic trimodal chemotherapeutic/photothermal/photodynamic treatment and demonstrated excellent antitumor effect, which is expected to have a greater potential for cancer therapy. (C) 2018 Elsevier Inc. All rights reserved.
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