期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 15, 期 1, 页码 252-263出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2018.10.004
关键词
Tumor angiogenesis; Molecular imaging; CT/MR dual-mode; Ultrasmall nanoparticle; Molecular pharmacokinetics
资金
- Natural Science Foundation of China [81701826]
- Youth Science Foundation of the Second Hospital Center Laboratory of Tianjin Medical University [2016ydey01, 2017ydey101]
- Key Program of the Tianjin Health and Family Planning Commission [16KG115]
- Science Foundation of Tianjin Medical University [2016KYZQ06]
Nonintrusive and precise imaging for tumor angiogenesis is critical in accurate assessment of cancer diagnosis and prognosis. However, reticulo-endothelial system (RES) capture and inadequate accumulation remain major bottlenecks for current nanoparticle to retain at tumor angiogenesis site. Herein, we report the ultrasmall contrast agent (cNGR-Au:Gd@GSH NMs) could accumulate at tumor vasculature site and enhance the tumor angiogenesis-contrast. It is demonstrated that by loading Au and Gd atom into the naturally-occurring glutathione (GSH) shell with cNGR peptide modification, cNGR-Au:Gd@GSH NMs exhibit the high X-ray photon absorption, longer rotational correlation time and efficient tumor vascular endothelia cell targeting. In vivo studies further indicate the cNGR-Au:Gd@GSH NMs prominently enhance tumor angiogenesis-contrast both on the computed tomography (CT) and magnetic resonance imaging (MRI) modalities by escaping the RES capture and target delivering. Our data imply that the cNGR-Au:Gd@GSH NMs may serve as the high-efficiency contrast agent to assess tumor angiogenesis in a nonintrusive technique. (C) 2018 Elsevier Inc. All rights reserved.
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