Biomedical applications of nanoceria: new roles for an old player

The use of different biomaterials with the ability to accelerate the repair and regeneration processes is of great importance in tissue engineering strategies. On this point, cerium oxide nanoparticles (CNPs or nanoceria) have recently attracted much attention due to their excellent biological properties including anti-oxidant, anti-inflammation and antibacterial activities as well as high angiogenic potential. The results of incorporation of these nano-sized particles into various constructs and scaffolds designed for tissue engineering applications have proven the success of this strategy in terms of improving healing process of different tissues. In this review, we first summarize the physicochemical and biological properties of nanoceria in brief and then present its usability in tissue engineering strategies based on the currently available published reports. Lay summary There have been several attempts to find innovative solutions for the regeneration of tissues and organs. Among different biomaterials, nanoceria has recently attracted much attention due to its excellent biological properties that advantageously add specific features to tissue engineering constructs.