期刊
NANO RESEARCH
卷 12, 期 4, 页码 749-757出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-019-2280-4
关键词
infrared imaging; myocardial infarct; Ag2S; nanodots; biological windows; Langendorff heart
类别
资金
- Ministerio de Economia y Competitividad de Espana [MAT2016-75362-C3-1-R, MAT2017-83111R]
- Instituto de Salud Carlos III [PI16/ 00812, CD17/00210]
- Comunidad Autonoma de Madrid [B2017/BMD-3867RENIMCM]
- European Commission Horizon 2020 project NanoTBTech
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal project [IMP18_38 (2018/0265)]
- COST action [CM1403]
- Instituto de Salud Carlos III
- European Structural and investment fond
Ag2S nanodots have already been demonstrated as promising near-infrared (NIR-II, 1.0-1.45 m) emitting nanoprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the potential application of functionalized Ag2S nanodots for accurate imaging of damaged myocardium tissues after a myocardial infarction induced by either partial or global ischemia. Ag2S nanodots surface-functionalized with the angiotensin II peptide (ATII) have shown over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an indirect evaluation of the damage level. The potential application of Ag2S nanodots in the near future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments.
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